Dimeric Proanthocyanidins from the Roots of Ephedra sinica

Abstract

Two new dimeric proanthocyanidins, ephedrannin B (2) and mahuannin E (4), along with two known congeners, ephedrannin A (1) and mahuannin D (3), were isolated from the roots of Ephedra sinica Stapf. Based on NMR, MS, and CD analysis, the structures of the new compounds were deduced to be 5,7,4′-trihydroxyflavan-[4(α)→8,2(α)→O→7]-kaempferol (2) and 5,7,4′-trihydroxyflavan-[4(β)→8,2(β)→O→7]-epi-afzelechin (4). The compounds 1 – 4 were evaluated for cytotoxicity against three tumor cell lines (SGC-7901, HepG2, and HeLa), and 2 was found to be significantly active.

Ephedra sinica Stapf - Ephedraceae - proanthocyanidins - ephedrannin B - mahuannin E - cytotoxicity

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